Publications of the Institute of Medical Physics and Biophysics in 2018

Authors:Schmidt A, Sauthof L, Szczepek M, Lopez MF, Escobar FV, Qureshi BM, Michael N, Buhrke D, Stevens T, Kwiatkowski D, von Stetten D, Mroginski MA, Krauß N, Lamparter T, Hildebrandt P, Scheerer P

Title:Structural snapshot of a bacterial phytochrome in its functional intermediate state

Journal:Nat Commun Year:2018; Volume:9Issue:(1):Pages:4912. doi: 10.1038/s41467-018-07392-7.

Authors:Flis J, Holm M, Rundlet EJ, Loerke J, Hilal T, Dabrowski M, Bürger J, Mielke T, Blanchard SC, Spahn CMT, Budkevich TV

Title:tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis

Journal:Cell Rep Year:2018; Volume:25Issue:(10):Pages:2676-2688.e7. doi: 10.1016/j.celrep.2018.11.040.

Authors:Scheerer P, Unger E, Tian L

Title:Protein structures guide the design of a much-needed tool for neuroscience

Journal:Nature Year:2018; Volume:561Issue:(7723):Pages:312-313. doi: 10.1038/d41586-018-06670-0. No abstract available.

Authors:Clément K, Biebermann H, Farooqi IS, Van der Ploeg L, Wolters B, Poitou C, Puder L, Fiedorek F, Gottesdiener K, Kleinau G, Heyder N, Scheerer P, Blume-Peytavi U, Jahnke I, Sharma S, Mokrosinski J, Wiegand S, Müller A, Weiß K, Mai K, Spranger J, Grüters A, Blankenstein O, Krude H, Kühnen P

Title:MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

Journal:Nature Med Year:2018; Volume:24Issue:(5):Pages:551-555. doi: 10.1038/s41591-018-0015-9. Epub 2018 May 7.

Authors:Saleh N, Kleinau G, Heyder N, Clark T, Hildebrand PW, Scheerer P

Title:Binding, Thermodynamics, and Selectivity of a Non-peptide Antagonist to the Melanocortin-4 Receptor

Journal:Front Pharmacol Year:2018; Volume:9Issue:(560):Pages:doi: 10.3389/fphar.2018.00560. eCollection 2018.

Authors:Klein W, Rutz C, Eckhard J, Provinciael B, Specker E, Neuenschwander M, Kleinau G, Scheerer P, von Kries JP, Nazaré M, Vermeire K, Schülein R

Title:Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

Journal:PLoS One Year:2018; Volume:13Issue:(12):Pages:e0208641. doi: 10.1371/journal.pone.0208641. eCollection 2018.

Authors:Khajavi N, Finan B, Kluth O, Müller TD, Mergler S, Schulz A, Kleinau G, Scheerer P, Schürmann A, Gudermann T, Tschöp MH, Krude H, DiMarchi RD, Biebermann H.

Title:An incretin-based tri-agonist promotes superior insulin secretion from murine pancreatic islets via PLC activation

Journal:Cell Signal Year:2018; Volume:51:Pages:13-22. doi: 10.1016/j.cellsig.2018.07.006. Epub 2018 Jul 25.

Authors:Borchert A, Kalms J, Roth SR, Rademacher M, Schmidt A, Holzhutter HG, Kuhn H, Scheerer P

Title:Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction

Journal:Biochim Biophys Acta Mol Cell Biol Lipids Year:2018; Volume:1863Issue:(9):Pages:1095-1107. doi: 10.1016/j.bbalip.2018.06.006. Epub 2018 Jun 5.

Authors:Tiemann JK, Rose AS, Ismer J, Darvish MD, Hilal T, Spahn CM, Hildebrand PW

Title:FragFit: a web-application for interactive modeling of protein segments into cryo-EM density maps

Journal:Nucleic Acids Res Year:2018; Volume:46Issue:(W1):Pages:W310-W314. doi: 10.1093/nar/gky424.

Authors:Qureshi BM, Behrmann E, Schöneberg J, Loerke J, Bürger J, Mielke T, Giesebrecht J, Noé F, Lamb TD, Hofmann KP, Spahn CMT, Heck M

Title:It takes two transducins to activate the cGMP-phosphodiesterase 6 in retinal rods

Journal:Open Biol Year:2018; Volume:8Issue:(8):Pages:pii: 180075. doi: 10.1098/rsob.180075.

Authors:Saleh N, Hucke O, Kramer G, Schmidt E, Montel F, Lipinski R, Ferger B, Clark T, Hildebrand PW, Tautermann CS

Title:Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor

Journal:Angew Chem Int Ed Engl Year:2018; Volume:57Issue:(10):Pages:2580-2585. doi: 10.1002/anie.201708764.

Authors:Bittner HJ, Guixà-González R, Hildebrand PW

Title:Structural basis for the interaction of the beta-secretase with copper

Journal:Biochim Biophys Acta Biomembr Year:2018; Volume:1860Issue:(5):Pages:1105-1113. doi: 10.1016/j.bbamem.2018.01.019.

Authors:Lamb TD, Heck M, Kraft TW

Title:Implications of dimeric activation of PDE6 for rod phototransduction

Journal:Open Biol Year:2018; Volume:8Issue:(8):Pages:pii: 180076. doi: 10.1098/rsob.180076.

Authors:Herrfurth N, Volckmar AL, Peters T, Kleinau G, Müller A, Cetindag C, Schonnop L, Föcker M, Dempfle A, Wudy SA, Grant SFA, Reinehr T, Cousminer DL, Hebebrand J, Biebermann H, Hinney A

Title:Relevance of polymorphisms in MC4R and BDNF in short normal stature

Journal:BMC Pediatr Year:2018; Volume:18Issue:(1):Pages:278. doi: 10.1186/s12887-018-1245-1.

Authors:Fischer J, Kleinau G, Rutz C, Zwanziger D, Khajavi N, Müller A, Rehders M, Brix K, Worth CL, Führer D, Krude H, Wiesner B, Schülein R, Biebermann H

Title:Evidence of G-protein-coupled receptor and substrate transporter heteromerization at a single molecule level

Journal:Cell Mol Life Sci Year:2018; Volume:75Issue:(12):Pages:2227-2239. doi: 10.1007/s00018-017-2728-1.

Authors:Flis J, Holm M, Rundlet EJ, Loerke J, Hilal T, Dabrowski M, Bürger J, Mielke T, Blanchard SC, Spahn CMT, Budkevich TV

Title:tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis

Journal:Cell Rep Year:2018; Volume:25Issue:(10):Pages:2676-2688.e7. doi: 10.1016/j.celrep.2018.11.040.

Authors:Nikolay R, Hilal T, Qin B, Mielke T, Bürger J, Loerke J, Textoris-Taube K, Nierhaus KH, Spahn CMT

Title:Structural Visualization of the Formation and Activation of the 50S Ribosomal Subunit during In Vitro Reconstitution

Journal:Mol Cell Year:2018; Volume:70Issue:(5):Pages:881-893.e3. doi: 10.1016/j.molcel.2018.05.003. Epub 2018 Jun 7..

Authors:Latorraca NR, Wang JK, Bauer B, Townshend RJL, Hollingsworth SA, Olivieri JE, Xu HE, Sommer ME, Dror RO

Title:Molecular mechanism of GPCR-mediated arrestin activation

Journal:Nature Year:2018; Volume:557Issue:(7705):Pages:452-456. doi: 10.1038/s41586-018-0077-3. Epub 2018 May 2.

Authors:Bräunig J, Dinter J, Höfig CS, Paisdzior S, Szczepek M, Scheerer P, Rosowski M, Mittag J, Kleinau G, Biebermann H

Title:The Trace Amine-Associated Receptor 1 Agonist 3-Iodothyronamine Induces Biased Signaling at the Serotonin 1b Receptor

Journal:Front Pharmacol Year:2018; Volume:12Issue:(9):Pages:222. doi: 10.3389/fphar.2018.00222. eCollection 2018.

Authors:Kalms J, Schmidt A, Frielingsdorf S, Utesch T, Gotthard G, von Stetten D, van der Linden P, Royant A, Mroginski MA, Carpentier P, Lenz O, Scheerer P

Title:Tracking the route of molecular oxygen in O2-tolerant membrane-bound [NiFe] hydrogenase

Journal:Proc Natl Acad Sci U S A Year:2018; Volume:115Issue:(10):Pages:E2229-E2237. doi: 10.1073/pnas.1712267115. Epub 2018 Feb 20.