Research Group Directed Evolution and Chemical Biology (Guillén Schlippe Lab)
The Guillén Schlippe lab works with in vitro selection and evolution methods as well as genetic reprogramming methods.
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Research in the lab includes:
- Enzymatic synthesis of extremely large and diverse libraries (1013) of bioactive peptides and miniature structural scaffolds.
- Discovery and application of bioactive peptide modulators that interrogate regulatory networks as both drug leads and molecular tools.
- Applying omic selections to RNA binding proteins to decipher relevant sequence determinants of RNA-protein interactions.