Signalling to and Repair of DNA

Two photolyase-related proteins termed PhrA and PhrB from the soil bacterium Agrobacterium tumefaciens are in the focus of our crystallographic studies.

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Bacterial Cpx (two-component) sensor regulator system CpxRAP

  • Crystal structures of isolated proteins and in complex with their interaction partners
  • Role of the Cpx two-component system as global modulator of cell envelope stress in Gram-negative bacteria

Financial Support

Charité – Universitätsmedizin Berlin

Collaboration Partners

Prof. Tilman Lamparter (Karlsruhe Institut of Technology - KIT), Prof. Marcus Elstner (KIT) and Dr. Norbert Krauß (Queen Mary University, London) and Prof. Sabine Hunke (Universität Osnabrück)