Signal transduction pathways - Signalling of G-Protein-coupled receptors (GPCR)

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The following GPCRs are in our present focus:

  • Rhodopsin and cone opsins (blue, green, red)
  • Melanopsin: Photoreceptor important for regulation of the circadian rhythm
  • TSHR receptor: human thyroid-stimulation hormone receptor
  • Oxytocin receptor - hormone and neurotransmitter oxytocin-GPCR
  • Histamine H2/H4 receptor: Human histamine receptor

Key Topics

  • Crystallisation and structure analysis of various GPCRs bound to agonists, inverse agonists or antagonists
  • Crystallisation and structure analysis of various GPCRs in complex with effector proteins or the effectors alone (G-proteins or arrestins)
  • Investigation of activation of one - or several signalling pathways, G-protein dependent or independent
  • Understanding the modulation of signal transduction (e.g. receptor activation or deactivation) and signal transduction pathways (e.g. G-protein coupling or arrestin) by disease causing mutations

Financial Support

Deutsche Forschungsgemeinschaft: Project SFB 740-B6, CharitéUniversitätsmedizin Berlin

Collaboration Partners

Dr. Norbert Krauß (Queen Mary University, London), PD. Dr. Peter W. Hildebrand, Dr. Michal Szczepek, Prof. Klaus Peter Hofmann, Dr. Martha Sommer, Prof. Franz Bartl, Prof. Duska Dragun, PD. Dr. Heike Biebermann and Dr. Gunnar Kleinau (all from the CharitéUniversitätsmedizin Berlin), Dr. Ralf Schülein (FMP, Berlin), Prof. Norbert Sträter (University Leipzig), Dr. Michael Heymann and Prof. Henry Chapman (all from CFEL – Hamburg), Prof. Hui-Woog Choe (Chonbuk National University, South Korea) and others.